The oldest child of John Depew and his wife Catharine was Isaac Depew, Sr., born in Sept 1758 in New Jersey. When the family moved to a farm near Fincastle in Botetourt County, VA. he moved with them, but at the age of 18 he enlisted in the militia to fight in the Revolutionary War. Per his pension application filed many years after the war, in 1776 and 1777 he served several 3 month tours of duty as a Private fighting the Cherokee Indians. These actions first brought him to be familiar with East TN. In 1780 he again joined the militia to repel the Cherokees, and earned the rank of Captain under Colonel Landon Carter.

In Oct 1780, Captain Isaac Depew was one of the 1040 volunteers from Tennessee called the Overmountain men who played a very significant role in defeating the British in the Battle of Kings Mountain. The men first gathered at Sycamore Shoals near Elizabethton, TN, and then marched 80 miles in 5 days across the mountains to join forces with about 400 North Carolina militia. Together they engaged the enemy led by Colonel Ferguson at Kings Mountain just below the South Carolina border. (Recall from a previous post about our Ayers ancestors in the Rev War, that Elihu and Nathaniel Ayers fought with the NC militia.) The victory at Kings Mountain proved decisive in defeating the British in the South and eventually in gaining American independence. Isaac Depew also stated that he later took part in the Battle of Guilford Courthouse in 1781.

After the war, Isaac returned home to Virginia. However, by 1784 he had relocated to East Tennessee. By occupation he was a wheelright, cabinet maker and a farmer. He also became active politically when in 1799 he was appointed Commissioner of Jonesborough and in 1801 Commissioner of Washington County. He eventually settled at Rock Springs, in Sullivan County.  Between 1787 and 1850 he bought and sold land on a regular basis and at one point had accumulated 3000 acres on and near Bays Mountain.

Isaac Depew, Sr. married twice, first to Jane Jones in 1780, and then after she died to Virginia Grimes, a widow in 1804.  Altogether, he was the father of seventeen children. According to reports, the Depews were deeply religious people and highly skilled workmen. Isaac Depew had heirs who were magistrates, physicians, farmers and soldiers. A grandson, The Reverend William P. Depew, to whom he had given substantial land became a preacher in the Methodist Church and was held in very high regard by all who knew him. He gave the land, organized and help build Depew’s Chapel and served as its pastor. Several Depews are buried in the Chapel cemetery including Captain Isaac Depew. The church, located in the shadow of Bays Mountain near Kingsport, TN, is still in use today.

Captain Isaac Depew was one of the most respected men in his county. However, he became the subject of general notoriety when he became opposed in principle to the Congressional Act of 1832 which established pensions for service in the Revolutionary War. His complaint was that it allowed pensions to persons able to support themselves. He believed the Act was too liberal in its provisions, and those who did not need the aid obtained it too easily. He personally possessed property and good health and the ability to subsist without aid from the government. It is totally unclear then, why Isaac Depew eventually filed his own application in 1852. By that time he was already 94 years old and other volunteers who could have provided testimony of his service had already died before him. So the application was turned down due to lack of sufficient proof, and he died in 1854 without providing any additional information.